|
Post by travelingrat on Jan 29, 2016 10:09:40 GMT -5
on the topic of "I got in some studies but not others" jesus people are we that ignorant? Is our understanding of science that limited, do you have any idea whats happening or why? Studies can, and often do have slightly different ranges & different requirements. A very slight change can be enough to knock you out of one, or let you clear for another. There are many standards ranges, but at anytime the sponsor, AND IT IS THE SPONSOR OR FDA, NOT THE CRU OR THE DOCTOR, can say "we want to reduce the tolerances and tighten such and such ranges". PPD or any CRU can't say, whoa, no way. It's the CRU job to conduct the study under the exact protocol provided by the sponsor, who, is bankrolling all of our paychecks. So yes, maybe now you are in range for what you once weren't, or maybe the ranges where wider on these other studies. The only way you know is to get your labs from each study and compare the ranges plus you're results and see if they line up. just as an addendum to this, slightly off-topic: while it is absolutely true that the sponsor sets the ranges fora particular study, i have been in a number of studies now where i was slightly out-of-range and the coordinator talked to the clinic doctor, who then phoned and discussed it with the sponsor. in all but one of these cases, the sponsor allowed me in. for example: for one study, my NaCl (salt) value was a teeny bit low. the sponsor agreed with the doctor that for that study, that ONE value did not matter since my EKG's are always perfect and my BP is nearly always 115/70, and every other lab value was fine. of course, i don't think the big assembly-line clinics do this (although i do know personally of one exception), unless it is for a study that is unusually hard to fill. smaller more personal clinics are more likely to do this, especially if you have been there before and they know you (and assuming one is a respectful and punctual and non-whining volunteer, which many are not). just adding this bit of info even though it is somewhat off-topic. some rats may never have been to a smaller clinic and not know this is possible and not know to ask if the sponsor can be contacted.
|
|
smiling4areason
Junior Member
I don't know what they gave me, but it sure seems to be working, I feel GREAT!
Posts: 72
|
Post by smiling4areason on Jan 29, 2016 19:01:50 GMT -5
some rats may never have been to a smaller clinic and not know this is possible and not know to ask if the sponsor can be contacted. "The situation you initally described is soing completely different, and common, anyway: you get in despite a lab value being out of range. Happens MOST of the time. Everyone knows that. It's "best labs," not "perfect labs." Everybody knows that. Many people will also know that the clinic may call the sponsor to get an official OK on a particularly imperfect set of labs." Absolutely correct. Many values have a Clinically Insignificant cushion. But things like ALT & TSH for instance, rarely are allowed out of range as well as several other key values that might be affected by the drug. If soing is off enough to get you bumped, it's either a somewhat serious health issue you should look into, or it's a specific value the the sponsor intends to measure. Again the pesky SCIENCE thing interfering with our dream job.
|
|
mike
Moderator
Posts: 334
|
Post by mike on Jan 29, 2016 19:08:01 GMT -5
If you don't even know what would cause a TSH test to suddenly be out of range and then be in range again, but comment here to tell me that I am the ignorant, then why respond to my question. Go educated yourself, ignorant ignoramus. Don't be troubled by trolls, flamers, or people who have a tired drum that they need to keep beating. Many people seem to think that because the thyroid involve hormones, that it can fluctuate wildly because of many factors, like with adrenalin or cortisol or estrogen or testosterone. This is not the case, it's rare that thyroid hormones quickly change to any large degree. I would be worried if you find that they actually are doing this. If you want to be really helpful, and more importantly if you really want an answer here, you could post what information that you have on your thyroid labs. To know what is going on we need to know what changes have occurred over what period of time with your TSH and T4 and T3.
|
|
|
Post by travelingrat on Feb 6, 2016 9:05:00 GMT -5
some rats may never have been to a smaller clinic and not know this is possible and not know to ask if the sponsor can be contacted. Are you actually saying that a volunteer who's just been told "you're cut from the study because of x lab value" can (and should!) ask the clinic to call the sponsor, and the clinic should, for God knows what reason, ask the sponsor to (a.) consider keeping that volunteer anyway, and INSTEAD (b.) cut one of the OTHER people who were JUST SELECTED? Why would the clinic do that? Why would you imagine that some kind of lobbying process like this exists, or that it can get you into a study? And why would you not have a problem with screwing someone else over like this? I surely have misunderstood you. The situation you initally described is soing completely different, and common, anyway: you get in despite a lab value being out of range. Happens MOST of the time. Everyone knows that. It's "best labs," not "perfect labs." Everybody knows that. Many people will also know that the clinic may call the sponsor to get an official OK on a particularly imperfect set of labs, because no one with better labs was found. This is typically soing one just overhears the physician discussing. But that's not what you seem to be describing in your final paragraph. You seem to be praising some kind of special treatment that, if you were actually able to obtain it (and you do sound more as if you're optimistically daydreaming about it than describing soing you've actually pulled off), would result in your walking across a more suitable volunteer's back to get into a study. Straighten me out here, O Voice of Reason. Are we revisiting your previous theme that since you're a Little Old Lady, so polite & good & whatnot, you deserve vitals taken in a private room, and now special phone calls to the sponsor on your behalf, too? (And please, for the love of God, keep your self-righteous whining about my tone, in your reply, to a minimum. Thanks.) gosh, i don't think you read posts very carefully. once again you are referring to a previous post of mine in which i described how SNBL re-took my BP in a private room. my point was that GOOD clinics screen EVERYONE in private rooms. places like SNBL, OCRC, AVAIL, etc etc, ALWAYS do. so yes, i suppose you could say there is "Special Treatment;" but it is for EVERYONE, not just sweet ole Traveling Rat! this was the point i was making in BOTH posts: if someone has problems in the big impersonal clinics where they herd the rats along, and yes, those places are usually quite noisy and NOT private, then try out some of the smaller and lesser-known clinics. and yes, not just for me, but for lots of persons, once a small clinic knows you, they will go the extra mile to get you in a study. think about it: it is cost-effective for them to try to enroll reliable, punctual, agreeable rats with overall good labs. they know the persons who are like that and they WANT them there. and no, i was NOT suggesting that this would be the case if my, or anyone's lab values, were WAY out of range. in the smaller clinics especially, it is easy to talk directly to your coordinator or to the doctor. you don't have to "overhear" them in the halls. you can talk directly to them about your chances of getting into the study you are trying for, and work with them to see if they can make it happen. the only problem with some of these small clinics is that is veeery hard to get into that first study. they contact their regulars first. one friend of mine only got into a certain clinic in Florida (and no, i would rather not say its name) when she had recommendations from 2 other women who have gone there for years. and, it is NOT always about the labs. personally i think it would be easier for everyone IF the persons with the BEST labs ALWAYS landed the study ings, in every clinic. but clinics can and do exclude persons for lots of reasons: on the basis of where they live, whether they have a good reputation at that clinic, even their attitude at screening. a clinic does not even have to submit the labs of someone they don't want there! i have talked to a a lot of staff over the years. if you or anyone think it is all about great labs, think again!! even at big clinics like Celerion AZ, with its supposedly absolutely fair call-in system, weird things happen. (talk to some celerion AZ regulars and you will hear a lot of anecdotes.) you seem to be trying hard to insult me but overall your remarks to me (and others) seem merely SILLY. it certainly is not going to upset me if you refer to my "Special Treatment" at SNBL, where as i said, EVERYONE gets "Special" Treatment. almost all the clinics i go to dole out that Special Treatment. so yay for them and yay for me, sweet little old lady that i am! for you, however, if your attitude in person is like your rude, hostile posts, don't bother applying to such clinics, because YOU. WILL. NOT. GET. IN. (or maybe you will get in ONE TIME.) but best wishes anyway!
|
|