Does anyone have any opinion on eye drop tests?

[puntkicker]

Hi, I was curious if any of you had any sort of knowledge or opinion of eye drop studies?  The drug is kpi-121, if that helps. I tend to want to protect my eyes and such, maybe a bit more than if I had side effects elsewhere.  I was just curious what folks thought(whether youve had experience or otherwise), being I havent seen this route of administration to be extremely common in my time on here.  Thanks

[FloridaGirl]

I have heard of out patient eye drop studies checking shampoo, OTC eye drops but I guess u need to find out if it is only one dose. I would not do it if it is multi dose. It must be for glaucoma, cataracts, dry eye. I guess u need to know the side effects.
I thought oral ( pills/drops/inhaler) and IV were the only forms of dosing.
I did do a Parkinson's study that was an inhaled powder which was strange but only one dose.

Wish I had more info. I will look up the drug and see what info available.

[FloridaGirl]

I saw that it is for dry eye. If it is out pt they usually pay a lot less so I guess u need to way the possible side effects with the $$$.
So if it is in patient they might be dosing every day . I would really have to think about that.
Covance had an IV antibiotic study and u got infused every 8 hrs, no thank you. It paid well but for me not worth it.

[respect]

If it can be done on an outpatient basis it must be deemed safer.

[FloridaGirl]

That's true then it has already gone thru phase 1 testing but puntkicker did not say so I was assuming it was phase 1.

[puntkicker]

Hi, thanks for the posts, folks! It's an inpatient study....15 days.... The drug itself is in phase 3, but Ive seen trials for 2 going on concurrently on some studies, so I dont know how that works. Isnt phase 3 supposed to be for folks with the dis, getting the actual therapeutic dose testing for efficacy? I suppose I could re-read all of that sometime, but the drug is already cleared for phase 3 and doing them, I think. If that's the case, why do they want us for?

Also, I couldnt find the study listed from the 3 or so current results on clinicaltrials.gov. Has anyone else ever experienced that?

Right now Ive got this, the cancer drug, a study with a genome screen that eliminates 50% of people, and a psoriasis drug. I'm not exactly enthralled with anything. I wish Max Headroom read all the threads, because I'm tempted to join him by hitting the bottle for the first time in a long time! The stress is starting to concern me....plus getting absolutely wasted(I wish I could naturally use the eloquent descriptions Max does, but this will have to do for now!) sounds like fun compared to the feeling all of this gives me!

[puntkicker]

One more thing I just remembered, that I think deserves a post of it's own, and could be soing bigger to the up and coming volunteers.....

The formulation of kpi-121 in these drops is nanoparticles. I'm guessing some folks on here know what those are, but I recall seeing one thing I was reading about the kpi-121 being capable of penatrating mucus, and it was written in a way that seemed to insinuate other eye drops did not. That made it seem a bit scary to me, though I'm not sure what others would think.  Any thoughts on nanoparticles and eyes?

Another thing... the brief summary on the clinic website listed it as a drug being tested for itchy and watery eye(and one other similar symptom). Isn't watery eye the opposite of dry eye?

I've finalized my travel now, so I guess I will know soon enough. I would think this will be helpful for future volunteers though, and would appreciating getting as much good information on here as we can. Thanks