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Post by subject on Mar 7, 2017 19:58:42 GMT -5
I am not sure why people are so adamant about making people post on a internet message board. You have to realize that most of these people in these studies view others as competition and rightfully so. Hence refraining from sharing vital information with other anonymous people who are likely to be competitors in an upcoming trial.
The numbers you see below: "Users Online in the Last 24 Hours 0 Staff, 12 Members, 261 Guests."
does not necessarily mean 261 PEOPLE visited the site. Many counters/analytic scripts take a unique IP address as a visitor/guest. If you include the google bots, spiders and such you are probably looking at around 30 UNIQUE IPs of a unique person or less that visited the site. If you really want a true estimate, just look at the "VIEWING" section on the main page.
"Information about Healthy Studies - 2 viewing" should give you a pretty fair estimate about how many people are on the board. Looking at that information, there is probably 1 other person other than myself at this time looking the board. Both of those estimates were taken at the same time, so theres 261 Guests in the last 24 hours but 2 people viewing the subforum, so which is it? 261 people or 2? It's 2.
So there isn't actually HUNDREDS of people that "leech" information and not post. Quite the contrary, there are probably less than 10 active posters and about 3 dozen people that check this board a month and many of them work for the CRO's (clinical trial organizations like Spaulding for instance).
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Post by subject on Feb 28, 2017 15:11:39 GMT -5
A migraine that lasted for about 9 months after dosing and short term memory problems but then again I had some short term memory problems (not too bad) before but this med seemed to exacerbate them. No more headaches but my short term memory got slightly better but not as good as before dosing, but then it may not have been from the medication.
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Post by subject on Oct 17, 2016 18:45:35 GMT -5
Does any one have any kind of excuse to jump a study you already started to join a way better one where I won't be banned permantly? You're the type of people that ruin it for everyone else. If you don't plan on sticking with a study if a better one comes around, learn to wait for a good one instead of screening and getting into any you can. If you jump, most people here will hope you get what is coming to you.
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Post by subject on Oct 11, 2016 13:12:00 GMT -5
Depends on if they enter it into the computer or not. If you never signed the main consent, probably not, because the tech has to enter the data into vct but there is a place where they actually fingerprint you and make you sign the VCT consent before signing the main consent so see if you're in another study or not. Also I believe screening visits show up from what I hear, don't quote me on that.
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Post by subject on Sept 28, 2016 6:13:01 GMT -5
I didn't think women were a race. Nevertheless the real reason why most clinical trials are conducted on men is because almost every single lab rat is male. As in the real rats/guinea pigs/dogs etc (animal studies). Researchers avoided using female animals for fear that their reproductive cycles and hormone fluctuations would confound the results of delicately calibrated experiments. More research is being conducted on both sexes because females generally have more side effects than males. The over-reliance on male animals and cells in preclinical research obscures key sex differences that could guide clinical studies and may harm females. Women will and still are often underrepresented in clinical trials carried out by drug companies and medical device manufacturers because putting female subjects in your experiment increases the variety in the results, no doubt slowing the march to get drugs onto the market and making money.
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Post by subject on Sept 26, 2016 0:13:13 GMT -5
Do they use VCT? I just want to update the list, I dont care much personally. That phone thing sounds a bit overboard for me to put much stock in them. Yes they use VCT, confirmed by me as of last month. No fingerprinting, just a VCT consent. They also still have the competitive phone call thing but there was a rumor that they are testing non competitive with a few trials (not sure though).
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Post by subject on Sept 26, 2016 0:07:37 GMT -5
No one here knows brother. It's all up to the principal investigator/sponsor to let you in or not. Just make sure your labs are fine at check in.
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Post by subject on Sept 26, 2016 0:04:08 GMT -5
I always try to research the drugs that are on clinicaltrials.gov before heading to screen. Most, if not ALL the places do not have up to date listings of the clinical trials at all which is really sad because it is required under law (FDAAA 801). As a matter of fact, only 2 times has it been properly listed out of the dozens I've participated in.
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Post by subject on Sept 17, 2016 18:54:49 GMT -5
puntkicker is right. Exercising can alter your physiology. Clinical studies show that it can affect liver function as well as WBC (White blood cell). Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P < 0.01) and remained increased for at least 7 days postexercise. Bilirubin, γGT and ALP remained within the normal range. The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice. www.ncbi.nlm.nih.gov/pmc/articles/PMC2291230/www.scielo.br/pdf/spmj/v121n1/16127.pdfStay with your study restrictions if you want to stay in the study. Many people get away with exercising or eating certain foods but you're literally rolling the dice. People's body can get used to exercising and thus not have elevated parameters but ultimaely you are still taking a risk, especially with weightlifting. Not only are you going to increase your creatine and liver functions, by building muscle you are creating tiny tears in your muscle. Your body then repairs them which could alter your levels because your body is technically wounded or going through repair. Caffeine can elevate your blood pressure and heart rate and grapefruit / some types of sour oranges can contain compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzyme's ability to break down many drugs for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effect when taking a drug. Since the investigational drug(s) are usually first in human trials, you are gambling with your own health by not following these restrictions as even the doctors do not know the full extent of what these drugs do to the human body. These side effects can greatly increase since certain fruits block the enzyme to breakdown many drugs, the amount of drug in the drug can be equal to taking 10x or even 100x+ the amount of the investigational drug and you may end up having life threatening adverse effects. These narrow parameters allow lab technicians and physicians the greatest diagnostic margin (blood work) by introducing no dietary variables into the procedure.
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Post by subject on Aug 4, 2016 16:07:34 GMT -5
Does NOVUM use VCT?
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Post by subject on Mar 3, 2016 15:58:48 GMT -5
After a donation of 500ml of blood, most people’s haemoglobin levels are back to normal after six to twelve weeks. (Although screening and some studies don't account for that much blood loss, these studies are done regarding blood donations). Some studies may require you to donate that much blood anyways. iron pills with vitamin c should help you restore those levels back. Vitamin C increases absorption. Increasing doses of vitamin C exhibited a dose-dependent response in iron absorption during concomitant administration in healthy volunteers, ranging from no change in ferrous sulfate absorption with ascorbic acid doses below 100mg to 48% increase in elemental iron 30mg absorption with 500mg ascorbic acid. www.ncbi.nlm.nih.gov/pubmed/13873150Collection of whole blood following a 500 ml (+/- 50 ml ) volunteer blood donation would be expected to decrease Hgb by 1 g/dL and hematocrit (hct) by 1-3 % in an average 75 Kg adult. While total blood volume will be replaced within hours by extracellular fluid transfer into intravascular space, red cell mass is replaced within 3-5 weeks in most donors. Current FDA guidelines allow allogeneic blood donations with a Hct >/= 38% or Hgb >/= 12.5 g/dL. The maximum whole blood collection volume is 10.5 mL per kilogram body weight. I am assuming the screening was a bit more sensitive, and was around 13g/dL+ , which is probably where your levels are. BUT from MY general experience, you will generally lose 1.2-2.0 g/dL after 24 hours of losing 500ml or around 1 pint of blood after plasma and blood levels off and replace fluid in your body. It will take 6-12 weeks to recover those levels, faster if you take iron supplements. Assuming that 10% of the iron is absorbed, the hemoglobin concentration may fully correct after 4 weeks in patients with moderate, uncomplicated iron deficiency (about 500–800 mg of iron, enough for 500 to 800 mL of packed red blood cells, or enough to raise the whole blood hemoglobin 2–3 g/dL). www.ncbi.nlm.nih.gov/pmc/articles/PMC2582401/Of note, a randomized controlled trial showed that incrementally higher doses of iron in elders with iron-deficiency anemia did not provide any additional benefit in iron status, and in fact caused more gastrointestinal upset. Patients aged 80 or older with iron-deficiency anemia were randomized to receive 15mg, 50mg, or 150mg elemental iron daily, which resulted in comparable increases in hemoglobin and ferritin after 60 days without any statistically significant differences among the three groups. However, the higher doses resulted in statistically significant increases in abdominal discomfort, nausea, vomiting, diarrhea, constipation, and black stools.
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